The Kerala Genome Data Centre (KGDC) is a pioneering initiative by the Kerala Development and Innovation Strategic Council (K-DISC) aimed at transforming Kerala's economy into a knowledge-based powerhouse. Positioned as a global centre of excellence in genomics and bioinformatics, KGDC utilises Kerala's rich biodiversity to drive groundbreaking research and innovation. This state-of-the-art genomic data centre empowers researchers, healthcare institutions, and businesses to unlock the potential of Kerala's unique genetic data, promising advancements in healthcare, conservation, and economic growth. Through its One Health Approach and High-performance Data Centre, KGDC aims to attract global interest, inspire collaborations, and propel Kerala to the forefront of scientific and economic development.